About DiagnOSAS

DiagnOSAS got started when we realised that the current practices in detecting sleep apnea leave much to be desired. We found that 20% to 35% of the patients referred to hospital with a suspician of sleep apnea need not have gone. At the same time a large number of people suffering from sleep apnea remain undiagnosed. Furthermore, the currently available detection methods are expensive, time consuming and uncomfortable.

Our solution

We developed the OSAsense platform: An accessible, fast, and cost effective screening tool for sleep apnea. Our primary goal: find patiënts with a significant risk of sleep apnea faster, cheaper and simpler.

Our approach

DiagnOSAS aims to practice evidence-based medicine and adhere to the guidelines of good clinical practice. In addition, we aim to fulfil a role in the education of general practitioners and patients regarding basic sleep hygiene measures and the signs, symptoms, diagnostics and treatment of sleep apnea.

About OSAsense

The OSAsense service consists of a validated online questionnaire as well as a continuous overnight registration of the haemoglobin saturation level in the blood (pulse oximetry). Through the combination of this data, the OSAsense algorithm is able to identify sleep apnea with a sensitivity and specificity of ~100% and >70%, respectively. Using OSAsense before referring patients to hospital has a number of significant benefits. Patients with a low risk of sleep apnea need not undergo expensive and inconvenient testing. Patients with a significant risk can be referred quickly and confidently to proper diagnosis and treatment.

Clinical validation

In March 2016, a pilot study was initiated in the general practice to validate the OSAsense algorithm in approximately 150 patients. The study was approved by the local medical ethical committee (METC) and is registered in the Dutch Trial Register (NTR5786). Financial support (€50 k) was received from the Dutch health insurance corporation Menzis to conduct the study (Pioneers in Healthcare Voucher 2015). The initial OSAsense algorithm was developed in collaboration with the sleep centre from the Medical Spectrum Twente, Enschede, The Netherlands, based on data from over 3.500 patients.

Technology

Platform

The OSAsense platform has been developed as a state-of-the-art cloud platform. The development of the platform has been guided by strict security and privacy constraints.
  • Privacy: the OSAsense platform has been developed in accordance with ISO27001, ISO27002, ISO27017, NEN7510 and ISAE3402
  • Compliance: the OSAsense platform has been developed in accordance with MDD regulations as a CE class 2b medical device

Algorithm

The OSAsense service employs a proprietary algorithm to score the overnight saturation and acceleration data that the pulse oximeter records and securely transmits to the OSAsense platform.
  • Raw-data: the OSAsense algorithm can process both traditional 10Hz saturation data as well as, raw plethysmography and acceleration data for improved data resolution and information density.
  • Deep learning: the OSAsense platform was implemented with 'big-data' in mind. OSAsense benefits from machine learning techniques to further improve its reasoning.

Pulse Oximeter

The OSAsense pulse oximeter has been developed especially for the OSAsense service. The OSAsense device is unique in how it stores the recorded data, enabling high resolution OSA-screening and opening up new possibilities for both research & diagnostics.
  • OSAsense Certified: The OSAsense service can be used with 'OSAsense certified' pulse oximeters only. Currently, two commercially available meters have been certified, the OSAsense pulse oximeter, and the Nonin WristOx 3150
  • Raw-data: the OSAsense algorithm can process both traditional 10Hz saturation data as well as, raw plethysmography and acceleration data for improved data resolution and information density.

Contact

DiagnOSAS B.V.
Hibbertsstraat 3b
7481 JC, Haaksbergen
the Netherlands
+31 53 478 75 29

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